UCLA Department of Chemistry and Biochemistry : UCLA Portal

Website:

Jeffrey Zink's Home Page.
Jeffrey Zink's Laboratory.

Work Email Address:

zink@chem.ucla.edu

Work Address:

Mol Sci Bldg 2505A

Lab Number:

1 (310) 825-8651

Work Phone Number:

1 (310) 825-1001

Professor
Chemistry and Biochemistry, Inorganic Chemistry, Physical Chemistry

Member
California NanoSystems Institute

A Short Biography:

Professor Zink received his B.S degree in Chemistry from the University of Wisconsin, and his PhD degree from the University of Illinois in 1970. He joined the faculty at UCLA in 1970.

Awards and Honors:

National Science Council of Taiwan Visiting Lecturer ; SUNY Buffalo Foster Chemistry Colloquium Lecturer ; US Department of Energy Materials Sciences Outstanding Scientific Accomplishment in Metals and Ceramic Sciences ; University of Amsterdam Invited Visiting Professor ; University of Oklahoma J. Clarence Karcher Lecturer ; University of Paris Invited Visiting Professor ; Dow-Hansen Distinguished Teaching Award ; John Simon Guggenheim Fellow

Research Interest:

Professor Zink and his research group work primarily in four areas: excited state properties of large molecules, laser assisted chemical vapor deposition of nano-particles and structures, functional (optical and electrical) nano-structured materials, and nano-machines. Research on excited states is currently focused on coupled potential energy surfaces with special emphasis on photo-induced electron transfer. The research on deposition makes use of excited state properties to design molecules and direct bond-breaking to lead to desired chemical compositions and nanostructures. Studies of functional nano-materials (especially films and nanoparticles) are currently focused on energy transfer and electron transfer at the nanoscale. Research on nano-machines is focused on rotating machines, oscillating "molecular impellers" and nano-valves. Operation of molecular machines attached to nanoparticles in living cells and applications to drug delivery are under active investigation.

Detailed Biography:

Professor Zink has been a Faculty member in the Department of Chemistry and Biochemistry since 1970. He received his B.S. degree in Chemistry at the University of Wisconsin. He came to UCLA after receiving his PhD degree from the University of Illinois under the direction of Russell S. Drago. He is a Distinguished Professor of Chemistry and a member of the California Nanosystems Institute. He has been an invited guest professor at the University of Paris VI and at the University of Amsterdam, and serves as an ACS tour speaker. He is an authority on triboluminescence, photochemistry and photophysics of metal-containing molecules, and on nanomachines, and has published almost 400 articles. His current research is focused on fundamental spectroscopic investigation of large metal-containing molecules and on design, operation and biological applications of functional nanomaterials including nanomachines such as valves and impellers.

Publications:

T. Xia, M. Kovochich, M. Liong, J. I. Zink, and A. E. Nel Cationic Polystyrene Nanosphere Toxicity Depends on Cell-Specific Endocytic and Mitochondrial Injury Pathways, ACSNANO, 2008; 2: 85-96.

K. Patel, S. Angelos, W. R. Dichtel, A. Coskun, Y. Yang, J. I. Zink, and J. F. Stoddart Enzyme-Responsive Snap-Top Covered Silica Nanocontainers, J. Am. Chem. Soc, 2008; 130: 2382-2383 .

E. Johansson, E. Choi, S. Angelos, M. Liong, and J. I. Zink Light-activated functional mesostructured silica, J Sol-Gel Sci Technol, 2008; 46: 313-322 .

J. Lu, M. Liong, S. Sherman, T. Xia, M. Kovochich, A. E. Nel, J. I. Zink, and F. Tamanoi Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells, Nanobiotechnol, 2008; 3: 89-95.

S. Angelos, M. Liong, E. Choi and J. I. Zink Mesoporous Silicate Materials as Substrates for Molecular Machines and Drug Delivery, Chem. Eng. J, 2008; 137: 4-13.

Jie Lu 1, Eunshil Choi 2, Fuyuhiko Tamanoi 1 *, Jeffrey I. Zink 2 Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells Small, 2008; 4(4): 421-426.

Sarah Angelos, Ying-Wei Yang, Dr., Kaushik Patel, J. Fraser Stoddart, Prof. , Jeffrey I. Zink, Prof. Nanovalves for Drug Delivery Angewandte Chemie International Edition, 2008; 47(12): 2222-2226.

S.F. Nelsen, A.E. Konradsson, M.N. Weaver, R. M. Stephenson, J. V. Lockard, Y.Zhao, and J.I. Zink Comparisons of Measured Rate Constants with Spectroscopically Determined Electron-Transfer Parameters, J.Phys.Chem. B, 2007; 111: 6776-6781 .

T.D. Nguyen, Y. Liu, S. Saha, K.C.-F. Leung, J.F. Stoddart, and J.I. Zink Design and Optimization of Molecular Nanovalves Based on Redox-Switchable Bistable Rotaxanes, J. Am. Chem. Soc, 2007; 129: 626-634.

X. Wang, J. Li, M.E. Thompson, and J.I. Zink Excited-State Distortions of Cyclometalated Ir (III) Complexes Determined from the Vibronic Structure in Luminescence Spectra, J. Am. Chem. Soc, 2007; 111: 3256-3262 .

J. Lu, M. Liong, J. Zink, and F. Tamanoi Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs, Small, 2007; 3: 1341-1346 .

S. Angelos, E. Johansson, J.F. Stoddart, and J.I. Zink Mesostructured Silica Supports for Functional Materials and Molecular Machines, Adv. Funct. Mater, 2007; 17: 2261-2271.

B. Dunn and J.I. Zink Molecules in Glass: Probes, Ordered Assemblies, and Functional Materials, Acc. Chem. Res, 2007; 40: 747-755.

F. P. Ow, B. Henderson, and J.I. Zink Multiple Photochemical Reaction Pathways in a Ni(II) Coordination Compound, Inorg. Chem, 2007; 46: 2243-2248.

E. Johansson and J. I. Zink Nanostructured Silica Thin Films Self-Assembled with Electron Donors and Acceptors to Measure Electron Tunneling, J. Am. Chem. Soc, 2007; 129: 14437-14443.

S. Saha, K.C.F. Leung, T. Nguyen, J.F. Stoddart, and J.I. Zink Nanovalves, Adv. Funct. Mater., 2007; 17: 685-693.

S. Angelos, E. Choi, F. Vogtle, L. DeCola, and J.I. Zink Photo-Driven Expulsion of Molecules from Mesostructure /Silica Nanoparticles, J.Phys.Chem. C, 2007; 111: 6587-6592.

X.Wang, G.Valverde-Aguilar, M. N. Weaver, S. F. Nelsen, and J.I. Zink Resonance Raman De-Enhancement Caused by Exited State Mixed Valence, J. Phys. Chem. A, 2007; 111: 5441-5447.

T.D. Nguyen, K.C.F. Leung, M. Liong, Y. Liu, J.F. Stoddart, and J.I. Zink Versatile Supramolecular Nanovalves Reconfigured for Light Activation, Adv. Funct. Mater., 2007; 17: 2101-2110.

F.P. Ow, M.T. Berry, P.S. May, and J.I. Zink Wavelength and Metal Dependence in the Photofragmentation of a Gas-Phase Lanthanide B-Diketonate Complex, J. Phys. Chem. A, 2007; 111: 4144-4149.

J.V. Lockard, J.I. Zink, Y. Luo, M.N. Weaver, J.W. Fowble, A.E. Konradsson, and S.F. Nelsen Excited-State Mixed Valence in a Diisopropyl Diphenyl Hydrazine Cation, J. Am. Chem. Soc., 2006; 128: 16524-16531.

T.D. Ngyuen, K. C.-F. Leung, M. Liong, C.D. Pentecost, J.F. Stoddart and J.I. Zink Construction of a pH-Driven Supramolecular Nanovalve, Org. Lett, 2006; 8: 3363-3366 .

Inorg. Chem Excited-State Mixed Valence in Transition Metal Complexes, E.A. Plummer and J.I. Zink, 2006; 45: 6556-6558.

J.V. Lockard, G. Valerde, D. Neuhauser, Y. Luo, M.N. Weaver, S.F. Nelsen and J.I. Zink Interpretation of Unusual Absorption Bandwidth and Resonance Raman Intensities in Excited State Mixed Valence, J. Am. Chem. Soc, 2006; 110: 57-66.

S.F. Nelsen, Y. Luo, M.N. Weaver, J.V. Lockard, and J.I. Zink Optical Spectra of Protected Diamine 10-Bond-Bridged Intervalence Radical Cations Related to N,N,N’N’-Tetraalkylbenzidine, J. Org. Chem., 2006; 71: 4286-4295 .

S.F. Nelson, A.E. Konradsson, M.N. Weaver, N. Michael, I.A. Guzei, M. Gobel, R. Wortmann, J.V. Lockard and J.I. Zink Photochemical Charge Separation within Aromatic Hydrazines and the Effect of Excited-State Intervalence Dihydrazines, J. Phys. Chem. A, 2006; 109: 10854-10861.

G. Valverde-Aguilar, X. Wang, S.F. Nelsen and J.I. Zink Photoinduced Electron Transfer in 2-tert-Butyl-3-(Anthracen-9-yl)-2,3-Diazabicyclo[2.2.2]Octane, J. Am. Chem. Soc, 2006; 128: 6180-6185 .

P. Sierocki, H. Maas, P. Dragut, G. Richardt, F. Voegtle, L. De Cola, F. Brower and J. I. Zink Photoisomerization of Azobenzene Derivatives in Nanostructured Silica, J. Phys. Chem. B, 2006; 110: 24390-24398 .

K. C.-F. Leung, T. D. Ngyuen, J.F. Stoddart and J.I. Zink Supramolecular Nanovalves Controlled by Proton Abstraction and Competitive Binding, Chem. Mater, 2006; 18: 5919-5928.

M.J. Poderycki, V.A. Kickhoefer, C.S. Kaddis, S. Ravel-Fernandes, E. Johansson, and J.I. Zink The Vault Exterior Shell is a Dynamic Structure that Allows Incorporation of Vault-Associated Proteins into its Interior, Biochem, 2006; 45: 12184.

S.F. Nelsen, M.N. Weaver, Y. Luo, J.V. Lockard and J.I. Zink Use of the Neighboring Orbital Model for Analysis of Electronic Coupling in Class III Intervalence Compounds, Chemical Physics, 2006; 324: 195-201 .

F.P. Ow, M.T. Berry, P.S. May, and J.I. Zink Wavelength Dependent Photofragmentation Patterns of Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)Ln (III) (Ln = En, Tb, Gd) in a Molecular Beam, J. Phys. Chem. A, 2006; 110: 7751-7754 .

Saha, S.; Johansson, E.; Flood, A. H.; Tseng, H.-R.; Zink, J. I.; Stoddart, J. F. "A photoactive molecular triad as a nanoscale power supply for a supramolecular machine.", Chemistry--A European Journal, 2005; 11(23): 6846-6858.

Nguyen, T. D.; Tseng, H.-R.; Celestre, P. C.; Flood, A. H.; Liu, Y.; Stoddart, J. F.; Zink, J. I. "A reversible molecular valve.", Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(29): 10029-10034.

Lockard, J. V.; Zink, J. I.; Trieber, D. A., II; Konradsson, A. E.; Weaver, M. N.; Nelsen, S. F. "Excited-State Mixed Valence in a Diphenyl Hydrazine Cation: Spectroscopic Consequences of Coupling and Transition Dipole Moment Orientation.", Journal of Physical Chemistry A, 2005; 109(6): 1205-1215.

Hsueh, H.-S.; Yang, C.-T.; Zink, J. I.; Huang, M. H. "Formation of Titanium Nitride Nanoparticles within Mesoporous Silica SBA-15.", Journal of Physical Chemistry B, 2005; 109(10): 4404-4409.

Minoofar, P. N.; Dunn, B. S.; Zink, J. I. "Multiply Doped Nanostructured Silicate Sol-Gel Thin Films: Spatial Segregation of Dopants, Energy Transfer, and Distance Measurements.", Journal of the American Chemical Society, 2005; 127(8): 2656-2665.

Lan, E. H.; Dunn, B.; Zink, J. I. "Nanostructured systems for biological materials.", Methods in Molecular Biology (Totowa, NJ, United States), 2005; 300: 53-79.

Nelsen, S. F.; Weaver, M. N.; Zink, J. I.; Telo, J. P. "Optical Spectra of Delocalized Dinitroaromatic Radical Anions Revisited.", Journal of the American Chemical Society, 2005; 127(30): 10611-10622.

Nelsen, S. F.; Konradsson, A. E.; Weaver, M. N.; Guzei, I. A.; Goebel, M.; Wortmann, R.; Lockard, J. V.; Zink, J. I. "Photochemical Charge Separation within Aromatic Hydrazines and the Effect of Excited-State Intervalence in Dihydrazines.", Journal of Physical Chemistry A, 2005; 109(48): 10854-10861.

Saha, S.; Johansson, L. E.; Flood, A. H.; Tseng, H.-R.; Zink, J. I.; Stoddart, J. F. "Powering a supramolecular machine with a photoactive molecular triad.", Small , 2005; 1(1): 87-90.

Kickhoefer, VA Garcia, Y Mikyas, Y Johansson, E Zhou, JC Raval-Fernandes, S Minoofar, P Zink, JI Dunn, B Stewart, PL Rome, LH Engineering of vault nanocapsules with enzymatic and fluorescent properties. Proceedings of the National Academy of Sciences of the United States of America. , 2005; 102(12): 4348-52.

Jeffrey Zink, Ph.D.