UCLA Chemistry and Biochemistry
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Louis Bouchard, Ph.D.

Work Email Address:

bouchard@chem.ucla.edu

Laboratory Address:

Young Hall 2104 and 2042
Student Office: Young Hall 3085

Work Address:

Department of Chemistry and Biochemistry
607 Charles E Young Dr East / Young Hall 3048B
University of California, Los Angeles, CA 90095
UNITED STATES

Work Phone Number:

1 (310) 825-1764
Assistant Professor
Chemistry and Biochemistry, Physical Chemistry
Member
California NanoSystems Institute, Biomedical Engineering Interdepartmental Program

A Short Biography:

Dr. Bouchard obtained a bachelor’s degree in physics and business management from McGill University in Montréal, Canada, a Master’s degree in medical biophysics from the University of Toronto and a Ph.D. in Chemistry from Princeton University. His doctoral dissertation explores the use of multiple quantum coherence and long-range dipolar interactions in condensed matter to characterize heterogeneous material microstructure. During his stay in the laboratory of Alex Pines at the University of California, Berkeley he developed novel approaches and methodologies to portable, low-field NMR and MRI, microfluidics and hyperpolarization methods to the study of chemical reactions. He joined the UCLA faculty during the summer of 2008 to pursue research in physical chemistry.

Awards and Honors:


Camille and Henry Dreyfus New Faculty Award (2008); Charlotte Elizabeth Procter University Honorific Fellowship at Princeton University (2003); University of Toronto Fellowship (1998).

Research Interest:

The Bouchard laboratory conducts research at the interface of chemistry, applied physics, nanoscience engineering and chemical engineering. There is a strong incentive for wanting to perform chemical reactions at the micro scale, including reduced costs and reduced chemical waste, but analytical methods still remain underdeveloped. In recent years, magnetic resonance imaging and hyperpolarization methods have proved to be powerful tools for the detailed study of chemical processes at the micro scale, including the elucidation of pathways during chemical transformations. The research includes detailed studies and development of novel methods for the study of micro flows, mechanistic and thermodynamic processes during chemical reactions occurring in microfluidic channels, with the aim of improving reaction efficiency, reactor design and understanding enzymatic and industrial catalytic processes.


Detailed Biography:

Dr. Bouchard joined the physical chemistry division of the Department of Chemistry and Biochemistry in 2008. He came to UCLA after doing postdoctoral research at UC Berkeley in materials science and chemistry. His areas of expertise include the development of novel methods for magnetic resonance imaging, microscopy and spectroscopy, collective quantum mechanical effects in nuclear spin ensembles, fluid mechanics and chemical reaction engineering. He is pursuing experimental research in the development of hyperpolarization methods to the detailed study of flows, in situ chemical reactions and metabolic processes in microfluidic devices.

Publications:

Franck JM, Demas V, Martin RW, Bouchard LS, Pines A   Shimmed matching pulses: Simultaneous control of rf and static gradients for inhomogeneity correction, Journal of Chemical Physics, 2009; 131: 234506.
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Acosta VM, Bauch E, Ledbetter MP, Waxman A, Bouchard LS, Budker D   Temperature dependence of the nitrogen-vacancy magnetic resonance in diamond, cond-mat.mes-hall, 2009; arXiv:0911.3938v2.
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Bouchard LS, Acosta VM, Bauch E, Budker D   Detection of the Meissner effect with a diamond magnetometer, cond-mat.supr-con, 2009; arXiv:0911.2533v1.
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Kelso N, Lee SK, Bouchard LS, Demas V, Muck M, Pines A, Clarke JC   Distortion-Free Magnetic Resonance Imaging in the Zero-Field Limit, Journal of Magnetic Resonance, 2009; 200: 285-290.
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Bouchard LS, Anwar MS, Liu GL, Hann B, Xie H, Gray JW, Wang X, Pines A, Chen FF   Picomolar Sensitivity MRI and Photoacoustic Imaging of Cobalt Nanoparticles, Proc. Natl. Acad. Sci. USA, 2009; 106: 4085-4089.
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Demas V, Franck JM, Bouchard LS, Sakellariou D, Meriles CA, Martin R, Prado PJ, Bussandri A, Reimer JA, Pines A   'Ex-Situ' magnetic resonance volume imaging, Chemical Physics Letters, 2009; 467: 398-401.
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Bouchard LS   "Shimming pulses" in Magnetic Resonance Microscopy: Spatially Resolved NMR Techniques and Applications, Wiley-VCH, 2009; Ed. Joseph D. Seymour and Sarah Codd: .
Paulsen JL, Franck J, Demas V, Bouchard LS   Least squares magnetic-field optimization for portable nuclear magnetic resonance magnet design, IEEE Transactions on Magnetics, 2008; 44: 4582-4590.
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Bouchard LS, Burt SR, Anwar MS, Kovtunov KV, Koptyug IV, Pines A   NMR imaging of catalytic hydrogenation in microreactors with the use of parahydrogen, Science , 2008; 319: 442–445 .
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Bouchard LS, Sushkov AO, Budker D, Ford JJ, Lipton AS   Nuclear-spin relaxation of 207Pb in ferroelectric powders, Physical Review A, 2008; 77: 022102.
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Verpillat F, Ledbetter MP, Budker D, Xu S, Michalak M, Hilty C, Bouchard LS, Antonijevic S, Pines A   Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor , Proc. Natl. Acad. Sci. USA, 2008; 105: 2271–2273 .
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Paulsen JL, Bouchard, LS, Graziani N, Bluemich B, Pines A   Volume selective magnetic resonance imaging using an adjustable, single-sided, portable sensor, Proc. Natl. Acad. Sci. USA, 2008; 105: 20601-20604.
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Jachmann RC, Trease D, Bouchard LS, Sakellariou D, Martin R, Schlueter RD, Budinger, TF, Pines A   Multipole shimming of permanent magnets using harmonic corrector rings, Review of Scientific Instruments , 2007; 78: 035115.
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Bouchard LS, Kovtunov KV, Burt SR, Anwar MS, Koptyug IV, Sagdeev RZ, Pines A   Parahydrogen-enhanced gas-phase magnetic resonance imaging, Angewandte Chemie Intl Ed , 2007; 46: 4064–4068 (ranked Very Important Paper).
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Anwar MS, Hilty C, Chu C, Bouchard LS, Pierce KL, Pines A   Spin coherence transfer in chemical transformations monitored by remote detection NMR, Analytical Chemistry , 2007; 79: 2806–2811 .
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Bouchard LS, Anwar MS   Synthesis of matched magnetic fields for controlled spin precession, Physical Review B , 2007; 76: 014430 .
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Bouchard LS   Unidirectional magnetic-field gradients and geometric-phase errors during Fourier encoding using orthogonal ac fields, Physical Review B , 2006; 74: 054103 .
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Bouchard LS, Warren WS   Multiple-quantum vector field imaging by magnetic resonance J. Magn. Reson., 2005; 177(1): 1-13.
Bouchard LS, Wehrli FW, Chin CL, Warren WS   Structural anisotropy and internal magnetic fields in trabecular bone: coupling solution and solid dipolar interactions J. Magn. Reson., 2005; 176(1): 27-36.
Ledbetter MP, Savukov IM, Bouchard LS, Romalis MV,   Numerical and experimental studies of long-range magnetic dipolar interactions J. Chem. Phys. , 2004; 121: 1454-65.
Bouchard LS, Warren WS   Tensorial character of magnetization diffusion in periodic lattices Phys. Rev. B, 2004; 70(224426): .
Tang XP, Chin CL, Bouchard LS, Warren WS, Wehlri FW   Observing Bragg-like diffraction via multiple couple nuclear spins Phys. Lett. A, 2004; 326: 114-25.
Shannon KL, Branca RT, Galiana G, Cenzano S, Bouchard LS, Soboyejo W, Warren WS   Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo Magn. Reson. Imaging, 2004; 22: 1407-12.
Chin CL, Tang XP, Bouchard LS, Saha PK, Warren WS, Wehrli FW   Isolating quantum coherences in structural imaging using intermolecular double-quantum coherence MRI J. Magn. Reson., 2003; 165(2): 309-14.
Bouchard LS, Rizi RR, Warren WS   Magnetization structure contrast based on intermolecular multiple-quantum coherences Magn. Reson. Med. , 2002; 48: 972-9.
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